Transcriptionally defined morphological subtypes of pancreatic ductal adenocarcinoma

T.G. Krieger, A. Sudy, F. Schicktanz, L. Tosti, J. Liebig, B. Konukiewitz, M. Rouault, A. Niesnerova, X. Qian, W. Weichert, R. Eils, K. Steiger & C. Conrad

DOI: 10.1101/2022.09.23.509133 (bioRxiv)

Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system

S. Schuth, S. Le Blanc, T.G. Krieger, J. Jabs, M. Schenk, N.A. Giese, M.W. Büchler, R. Eils, C. Conrad & O. Strobel

DOI: 10.1186/s13046-022-02519-7 (Journal of Experimental & Clinical Cancer Research)

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

T.G. Krieger, S. Le Blanc, J. Jabs, F.W. Ten, N. Ishaque, K. Jechow, O. Debnath, C. Leonhardt, A. Giri, R. Eils, O. Strobel & C. Conrad

DOI: 10.1038/s41467-021-26059-4 (Nature Communications)

Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19

S. Trump, S. Lukassen, M.S. Anker, R.L. Chua, J. Liebig, L. Thürmann, V.M. Corman, M. Binder, J. Loske, C. Klasa, T.G. Krieger, B.P. Hennig, M. Messingschlager, F. Pott, J. Kazmierski, S. Twardziok, J.P. Albrecht, J. Eils, S. Hadzibegovic, A. Lena, B. Heidecker, T. Bürgel, J. Steinfeldt, C. Geoffinet, F. Kurth, M. Witzenrath, M.T. Völker, S.D. Müller, U.G. Liebert, N. Ishaque, L. Kaderali, L.E. Sander, C. Drosten, S. Laudi, R. Eils, C. Conrad, U. Landmesser & I. Lehmann

DOI: 10.1038/s41587-020-00796-1 (Nature Biotechnology)

Functional States in Tumor-Initiating Cell Differentiation in Human Colorectal Cancer

M.K. Zowada, S.M. Tirier, S.M. Dieter, T.G. Krieger, A. Oberlack, R.L. Chua, M. Huerta, F.W. Ten, K. Laaber, J. Park, K. Jechow, T. Müller, M. Kalxdorf, M. Kriegsmann, K. Kriegsmann, F. Herbst, J. Krijgsveld, Martin Schneider, R. Eils, H. Glimm, C. Conrad & C.R. Ball

DOI: 10.3390/cancers13051097 (Cancers)

Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

T.G. Krieger, S.M. Tirier, J. Park, K. Jechow, T. Eisemann, H. Peterziel, P. Angel, R. Eils & C. Conrad

DOI: 10.1093/neuonc/noaa091 (Neuro-Oncology)

Automated 3D light-sheet screening with high spatiotemporal resolution reveals mitotic phenotypes

B. Eismann, T.G. Krieger, J. Beneke, R. Bulkescher, L. Adam, H. Erfle, C. Herrmann, R. Eils & C. Conrad

DOI: 10.1242/jcs.245043 (Journal of Cell Science)

Pheno-seq–linking visual features and gene expression in 3D cell culture systems

S.M. Tirier, J. Park, F. Preußer, L. Amrhein, Z. Gu, S. Steiger, J.P. Mallm, T.G. Krieger, M. Waschow, B. Eismann, M. Gut, I.G. Gut, K. Rippe, M. Schlesner, F. Theis, C. Fuchs, Claudia R Ball, H. Glimm, R. Eils & C. Conrad

DOI: 10.1038/s41598-019-48771-4 (Scientific Reports)

Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development

T.G. Krieger, C.M. Moran, A. Frangini, W.E. Visser, E. Schoenmakers, F. Muntoni, C.A. Clark, D. Gadian, W.K. Chong, A. Kuczynski, M. Dattani, G. Lyons, A. Efthymiadou, F. Vargha-Khadem, B. D. Simons, K. Chatterjee & F.J. Livesey

DOI: 10.1073/pnas.1908762116 (PNAS)

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

O. Basak, T.G. Krieger, M.J. Muraro, K. Wiebrands, D.E. Stange, J. Frias-Aldeguer, N.C. Rivron, M. van de Wetering, J.H. van Es, A. van Oudenaarden, B.D. Simons & H. Clevers

DOI: 10.1073/pnas.1715911114 (PNAS)

Dynamic stem cell heterogeneity

T.G. Krieger & B.D. Simons

DOI: 10.1242/dev.101063 (Development)

Deterministic progenitor behavior and unitary production of neurons in the neocortex

P. Gao, M.P. Postiglione, T.G. Krieger, L. Hernandez, C. Wang, Z. Han, C. Streicher, E. Papusheva, R. Insolera, K. Chugh, O. Kodish, K. Huang, B.D. Simons, L. Luo, S. Hippenmeyer & S.H. Shi

DOI: 10.1016/j.cell.2014.10.027 (Cell)